Ozempic and the Weight Loss Revolution: Miracle Drug or Risky Trend?
In recent years, Ozempic has transitioned from a diabetes medication to a widely discussed weight loss solution. Originally developed to manage type 2 diabetes, its unexpected side effect of significant weight reduction has brought it a lot of attention. But what exactly is Ozempic, and does it live up to the hype?
Ozempic is the brand name for semaglutide, a medication developed by a company called “Novo Nordisk” based in Denmark. Approved by the FDA in 2017, it belongs to a class of drugs known as GLP-1 receptor agonists. These drugs mimic the action of the glucagon-like peptide-1 hormone, which plays an important role in regulating blood sugar levels by stimulating insulin secretion and inhibiting glucagon release. Additionally, Ozempic slows gastric emptying, leading to prolonged feelings of fullness and reduced appetite.
The development of semaglutide has a unique origin story. Researchers studying the Gila monster, a venomous lizard native to the southwestern United States, discovered that a component of its saliva mimicked the GLP-1 hormone. This source led to the creation of GLP-1 receptor agonists like semaglutide, helping scientists create a new class of medications targeting both diabetes and obesity.
Ozempic functions by enhancing insulin secretion in response to elevated blood sugar levels, suppressing glucagon release, and slowing gastric emptying. These effects not only aid in blood sugar control but also contribute to weight loss. Clinical studies have shown that patients using Ozempic experienced significant weight reduction, making it a dual-purpose medication.
While Ozempic offers notable benefits, it's essential to be aware of potential side effects. Common side effects include nausea, vomiting, diarrhea, abdominal pain, and constipation, especially during the initial stages of treatment. More serious risks, though rare, include pancreatitis, kidney problems, and potential thyroid tumors. Individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should avoid using Ozempic.
The popularity of Ozempic for weight loss has also led to increased off-label use, sometimes without medical supervision. This trend has given rise to counterfeit products sold online, posing significant health risks. Some individuals have suffered severe side effects, including coma, after using fake "Ozempic" injections purchased from unverified sources.
Ozempic represents a significant advancement in the treatment of type 2 diabetes and offers promising potential for weight loss. However, it's crucial to approach its use with caution, under the guidance of a qualified healthcare professional. The emergence of counterfeit products and off-label use underscores the importance of obtaining medications through legitimate channels and adhering to prescribed guidelines.
Written By: Zlata Lukovych
Sources:
Ms, M. G. R. (2025, March 7). Ozempic: Overview, how it works, and more. Healthline. https://www.healthline.com/health/drugs/ozempic
Ozempic (semaglutide): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD. (n.d.). https://www.webmd.com/drugs/2/drug-174491/ozempic-subcutaneous/details
The rise of Ozempic: how surprise discoveries and lizard venom led to. (2024, April 1). https://medicine.uq.edu.au/article/2024/04/rise-ozempic-how-surprise-discoveries-and-lizard-venom-led-new-class-weight-loss-drugs
JackW. (n.d.). What is Ozempic? Diabetes UK. https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/semaglutide/ozempic#:~:text=0345%20123%202399.-,How%20does%20Ozempic%20work%3F,how%20quickly%20food%20is%20digested.
Pa-C, J. F. M. (2025, April 14). How does Ozempic work? Understanding GLP-1s for diabetes, weight loss, and beyond. Harvard Health. https://www.health.harvard.edu/staying-healthy/how-does-ozempic-work-understanding-glp-1s-for-diabetes-weight-loss-and-beyond
Collins, S. (2024, July 16). Ozempic side effects. WebMD. https://www.webmd.com/obesity/ozempic-side-effects
